化合物Otenzepad T16411

Product Introduction
Bioactivity


英文名: Otenzepad

描述: Otenzepad (AF-DX 116) 是 M2 mAChR 的特异性拮抗剂，对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。

体内活性: In rats, Otenzepad (2 mg/kg; s.c.) significantly improved retention relative to vehicle controls. Otenzepad (0.5, 1 mg/kg; s.c.) significantly improved win-stay acquisition[1]. In mice, Otenzepad (0.3, 1.0, or 3.0 mg/kg, i.p.) reverses the effects of insulin on memory and potentiates the effects of glucose[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 24 mg/mL (56.93 mM)


关键字: Muscarinic acetylcholine receptor | Inhibitor | Otenzepad | mAChR | inhibit | AF-DX116 | memory | AF-DX-116

相关产品: Dimethindene | Lobelin | Dibucaine | Aclidinium bromide | SKF-83566 | PHA 543613 | Arecoline | Epiberberine chloride | JHU37152 | 5-AAM-2-CP

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | ReFRAME Related Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途