氧托溴铵 T16417

Product Introduction
Bioactivity


英文名: Oxitropium Bromide

描述: Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.

体外活性: Incubation with Oxitropium bromide of the untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro; but, it induces both types of muscle to be fatigue resistant. Oxitropium bromide is a muscarinic antagonist that blocks musucarinic acetylcholine receptors (mAChR) [1].

体内活性: Oxitropium bromide strongly and persistently inhibits the acetylcholine (ACh)-induced resistance. The increase in resistance induced by histamine, serotonin, leukotriene D4, or antigen is prevented by Oxitropium bromide Oxitropium bromide. Oxitropium bromide inhalation shifts force-frequency curves upward at 2 h after inhalation and inhibits the decrease of force-frequency curves due to endotoxin injection in vivo. Inhalation of the anticholinergic agent Oxitropium bromide at doses of 1.5 μg and higher greatly attenuates the decrease in mucus score produced by intravenous histamine but not by inhaled histamine [1][2][3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Oxitropium Bromide

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途