化合物 T16424 T16424

Product Introduction
Bioactivity


英文名: p38 MAPK-IN-1

描述: p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).

体内活性: p38 MAPK-IN-1 dose-dependently inhibits TNFα production (ED50: 0.5 mg/kg). p38 MAPK-IN-1 (1 mg/kg for iv and 10 mg/kg for p.o.) has a t1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a Cmax of 5.3 μM for p.o. in male wistar rats[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 8.33 mg/mL (23.84 mM)


关键字: p-38 MAPK-IN-1 | p38 MAPK-IN-1 | p38 MAPKIN1 | p38 MAPK IN 1

相关产品: Veraguensin | SD-169 | BMS582949 | Pexmetinib | PF-03715455 | 8-Prenylkaempferol | Talmapimod | Lucidenic acid F | Esculin sesquihydrate | Solamargine

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途