化合物Pan-RAS-IN-1 T16432
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 1835283-94-7 | ¥643.00 | 询底价 |
50 mg | 1835283-94-7 | ¥4,870.00 | 询底价 |
1 mL | 1835283-94-7 | ¥1,630.00 | 询底价 |
100 mg | 1835283-94-7 | ¥7,290.00 | 询底价 |
10 mg | 1835283-94-7 | ¥1,620.00 | 询底价 |
25 mg | 1835283-94-7 | ¥3,250.00 | 询底价 |
5 mg | 1835283-94-7 | ¥987.00 | 询底价 |
1 mg | 1835283-94-7 | ¥469.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pan-RAS-IN-1
描述: Pan-RAS-IN-1是一种广谱的 Ras 抑制剂。Pan-RAS-IN-1破坏 Ras 蛋白及其作用子的相互作用。
体外活性: Pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition at some concentrations. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment. Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity of less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on the expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range [1].
体内活性: Pan-RAS-IN-1-treated mice show decreased tumor pERK levels compared with vehicle-treated mice. Pan-RAS-IN-1 administration causes inhibition of tumor growth over 15 days of treatment. A modest increase in cleaved caspase-3 is also observed, showing that pan-RAS-IN-1 has the capacity to induce caspase activation in this model[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 50 mg/mL (69.67 mM)
关键字: PanRASIN1 | inhibit | Pan-RAS-IN-1 | Ras | Pan RAS IN 1 | Inhibitor
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相关库: Anti-Prostate Cancer Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | GPCR Compound Library | Anti-Obesity Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途