化合物PH-002 T16518
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1311174-68-1 | ¥5,680.00 | 询底价 |
10 mg | 1311174-68-1 | ¥1,830.00 | 询底价 |
25 mg | 1311174-68-1 | ¥3,990.00 | 询底价 |
1 mL | 1311174-68-1 | ¥1,170.00 | 询底价 |
5 mg | 1311174-68-1 | ¥995.00 | 询底价 |
1 mg | 1311174-68-1 | ¥428.00 | 询底价 |
100 mg | 1311174-68-1 | ¥7,930.00 | 询底价 |
Product Introduction
Bioactivity
英文名: PH-002
描述: PH-002 是一种抑制载脂蛋白 E4 神经内分子相互作用的抑制剂(IC50:116 nM)。
体外活性: PH-002 是一种抑制神经细胞内apolipoprotein (apo) E4 分子内域相互作用的抑制剂,其半最大抑制浓度(IC50)为116 nM(FRET检测)[1]。
体内活性: PH-002 (100 nM) enhances dendritic spine development in primary neurons from NSE-apoE4 transgenic mice to levels comparable with those in NSE-apoE3 primary neurons (apoE3-expressing primary neurons treated with PH-002 gave results identical to untreated primary neurons). PH-002 is also shown to enhance COX1 levels in primary neurons from the NSE-apoE4 transgenic mouse cortex and hippocampus. COX1 levels are increased by ~60% after 4 days of treatment with PH-002 (200 nM) [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 75 mg/mL (152.57 mM)
关键字: PH-002 | inhibit | Inhibitor | PH002 | PH 002
相关库: Bioactive Compounds Library Max | Inhibitor Library | PPI Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途