化合物Pico145 T16532
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 1628287-16-0 | ¥12,500.00 | 询底价 |
25 mg | 1628287-16-0 | ¥6,850.00 | 询底价 |
1 mg | 1628287-16-0 | ¥1,160.00 | 询底价 |
10 mg | 1628287-16-0 | ¥4,280.00 | 询底价 |
5 mg | 1628287-16-0 | ¥2,890.00 | 询底价 |
1 mL | 1628287-16-0 | ¥2,990.00 | 询底价 |
50 mg | 1628287-16-0 | ¥9,270.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pico145
描述: Pico145 (HC-608) 是有效的瞬时受体电位通道蛋白 1/4/5 (TRPC1/TRPC4/TRPC5) 抑制剂,在细胞中,抑制 (-)-englerin A 活化TRPC4/TRPC5 通道的IC50分别为 0.349 和 1.3 nM。
体外活性: Pico145 is a remarkable small-molecule inhibitor of TRPC1/4/5 channels. Pico145 displays no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8. Pico145 inhibits (?)-englerin A-activated TRPC4/TRPC5 channels (IC50s: 0.349 and 1.3 nM in cells). Pico145 also inhibits human TRPC4-TRPC1 and TRPC5-TRPC1 concatemers expressed in HEK 293 Tet+ cells (IC50, 0.03 nM, and 0.2 nM, respectively). Pico145 effectively inhibits RPC4-TRPC1 channels activated by sphingosine 1-phosphate (S1P) and suppresses S1P-evoked Ca2+ entry through TRPC4-TRPC1 channels (IC50: 0.011 nM). The potency of Pico145 can be reduced by increased (?)-englerin A concentration. Pico145 also sensitizes EA-sensitive cancer cell line (Hs578T cells) (IC50, 0.11 nM). Pico145 (100 nM) lacks effect on store-operated Ca2+ entry and histamine-evoked Ca2+ entry into endothelial cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 99 mg/mL (188.61 mM)
关键字: TRP Channel | Transient receptor potential channels | Pico145 | inhibit | HC608 | Pico-145 | Inhibitor | HC 608 | Pico 145
相关产品: JT010 | HC-030031 | AM-0902 | Ononetin | Podocarpic acid | 8-Gingerol | TRPM4-IN-2 | Olvanil | GSK1016790A | A-1165442
相关库: Ion Channel Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途