化合物 T16544 T16544
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 81045-50-3 | ¥10,600.00 | 询底价 |
100 mg | 81045-50-3 | ¥17,500.00 | 询底价 |
50 mg | 81045-50-3 | ¥13,800.00 | 询底价 |
2 mg | 81045-50-3 | ¥3,490.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pivalopril
描述: Pivalopril is a new orally active inhibitor of angiotensin-converting enzyme.
体内活性: Pivalopril is a new compound with a hindered sulfur group that has been compared to Captopril for oral angiotensin-converting enzyme (ACE) inhibition in rats and dogs and antihypertensive activity in rats. Pivalopril (incremental doses of 0.01-1.0 mg/kg, p.o.) produces a dose-related antagonism of AngI pressor effects, in conscious normotensive dogs. The ED50 is 0.17 mg/kg for Pivalopril and 0.06 mg/kg for Captopril. Pivalopril (100 mg/kg per day) decreases mean arterial pressure more effectively than Captopril (100 mg/kg per day). It is concluded that Pivalopril is a potent, orally effective ACE inhibitor and antihypertensive agent. In sodium-deficient, conscious spontaneously hypertensive rats (SHR), Pivalopril (1-100 mg/kg, p.o.) produces a dose-related reduction in mean arterial pressure. Pivalopril (0.03-1.0 mg/kg, orally [p.o.]) produces a dose-related antagonism of angiotensin I (AngI)-induced pressor effects, in separate groups of conscious normotensive rats. The ED50 for Pivalopril and Captopril is 0.1 mg/kg. At equieffective doses, the two compounds have similar durations of action. The potency and duration are similar to those of Captopril. In the sodium-replete SHR, 5 days of oral dosing with [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: RHC3659 | RHC-3659 | RHC 3659 | Pivalopril
相关产品: Vicenin 3 | Leucosceptoside A | Plantainoside D | Angiotensin III, human, mouse | ZD 7155 hydrochloride | Saralasin acetate(34273-10-4 free base) | Vicenin 2 | Angiotensin II human | L-162,313 | Sacubitril/Valsartan
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途