化合物 T16574 T16574
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 1852-38-6 | ¥455.00 | 询底价 |
2 mg | 1852-38-6 | ¥269.00 | 询底价 |
10 mg | 1852-38-6 | ¥728.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pregnenolone monosulfate sodium salt
描述: Pregnenolone monosulfate sodium salt is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone monosulfate sodium salt can protect the brain from cannabis intoxication. Pregnenolone monosulfate sodium salt acts as a signaling-specific inhibitor of the cannabinoid CB1 receptor. Pregnenolone monosulfate sodium salt also inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors.
体外活性: Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy. The effect of THC is obviously attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in the paired-pulse ratio induced by THC but does not modify either the amplitude or the decay time of miniature EPSC [1].
体内活性: Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and decrease the break-point in a progressive ratio schedule. Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Pregnenolone monosulfate sodium salt | 3b-Hydroxy-5-pregnen-20-one monosulfate sodium | 3beta-Hydroxy-5-pregnen-20-one monosulfate sodium | Pregnenolone monosulfate sodium | 3β-Hydroxy-5-pregnen-20-one monosulfate sodium
化合物 T16574 T16574信息由TargetMol中国为您提供,如您想了解更多关于化合物 T16574 T16574报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途