褪黑素 T1659

Product Introduction
Bioactivity


英文名: Melatonin

描述: Melatonin (Melatonine) 是一种由松果体制成的激素，可激活褪黑激素受体。它在睡眠中起作用，有抗氧化和抗炎特性。它是新型选择性ATF-6抑制剂，可诱导细胞凋亡。

体内活性: Melatonin increases the levels of activated PTEN, RSK-1, mTOR and AMPKα kinases, mildly inhibits ERK-1/2 phosphorylation and Bad phosphorylation, significantly inhibits phosphorylations of S6 Ribosomal Protein, 4E-BP1, GSK-3α and GSK-3β, and slightly increases PRAS40 phosphorylation in animals[5]. Melatonin ameliorates the neurotoxiciy and astrocyte activation induced by Aβ1-42 in the cerebral cortex. Melatonin also blocks the reduction in Reelin and Dab1 expression induced by Aβ1-42[2]. Melatonin treatment and lack of NLRP3-/- share similar inhibition of NF-κB and NLRP3 signaling pathway in mice. Melatonin treatment and lack of NLRP3-/- share some patterns of clock genes expression, and improve cardiomyocytes morphology in mice[6].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: 5% DMSO+95% Saline : 0.58 mg/mL (2.5 mM, suspension)
DMSO : 55 mg/mL (236.78 mM)


关键字: inhibit | Apoptosis | Mitophagy | Autophagy | Melatonin Receptor | Endogenous Metabolite | Mitochondrial Autophagy | Melatonin | Inhibitor

相关产品: Dibucaine | Elziverine | Syntide 2 acetate(108334-68-5 free base) | AC3-I, myristoylated | KN-92 hydrochloride | KN-92 phosphate | Y-33075 dihydrochloride | STO-609 | W-7 hydrochloride | CaMKIIα-PHOTAC

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Traditional Chinese Medicine Monomer Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途