化合物 T16683 T16683

Product Introduction
Bioactivity


英文名: Pumosetrag Hydrochloride

描述: Pumosetrag Hydrochloride is an orally available 5-HT3 partial agonist. It is developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.

体内活性: Pumosetrag delays liquid gastric emptying in association with the relaxation of the proximal stomach stimulates fasting antroduodenal migrating motor complex activity and accelerates small intestinal transit. Pumosetrag displays little to no response in the regions of the mouse intestine. Pumosetrag shows both regional and species specificities. Pumosetrag has lower efficacy than 5-HT in the rat jejunum, ileum, and distal colon. However, it has a similar efficacy and potency to 5-HT in the rat proximal colon. The activity profile of Pumosetrag is different in the guinea pig intestine where it exhibits greater potency and efficacy than 5-HT in all regions. Responses to Pumosetrag in the rat and guinea pig tissues are inhibited by ondansetron, confirming its action on 5-HT(3) receptors[1] [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (88.28 mM)


关键字: DDP733 | Pumosetrag Hydrochloride | DDP 733 | MKC 733 | MKC733

相关产品: Loxapine succinate | Escin IB | Quetiapine | Piperacetazine | Mirtazapine D3 | Vortioxetine hydrobromide | SKF-83566 | Hymenidin | Donitriptan hydrochloride | Granisetron

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途