化合物R-268712 T16708
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 879487-87-3 | ¥549.00 | 询底价 |
100 mg | 879487-87-3 | ¥5,970.00 | 询底价 |
1 mL | 879487-87-3 | ¥981.00 | 询底价 |
1 mg | 879487-87-3 | ¥378.00 | 询底价 |
50 mg | 879487-87-3 | ¥4,230.00 | 询底价 |
25 mg | 879487-87-3 | ¥2,820.00 | 询底价 |
10 mg | 879487-87-3 | ¥1,380.00 | 询底价 |
5 mg | 879487-87-3 | ¥892.00 | 询底价 |
Product Introduction
Bioactivity
英文名: R-268712
描述: R-268712 是选择性的 ALK5 抑制剂(IC50:2.5 nM)。
体外活性: R-268712 is a novel and specific inhibitor of activin receptor-like kinase 5 (ALK5), a transforming growth factor β (TGF-β) type I receptor.?Evaluation of in vitro inhibition indicated that R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5nM, an approximately 5000-fold more selectivity for ALK5 than p38 mitogen-activated protein kinase (MAPK).
体内活性: Oral administration of R-268712 at doses of 1, 3 and 10mg/kg also inhibited the development of renal fibrosis in a dose-dependent manner in a unilateral ureteral obstruction (UUO) model.?Additionally, the efficacy of R-268712 in a heminephrectomized anti-Thy1 glomerulonephritis model at doses of 0.3 and 1mg/kg.?R-268712 reduced proteinuria and glomerulosclerosis significantly with improvement of renal function.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 110 mg/mL (302.7 mM)
关键字: renal fibrosis | Thy1 nephritis | Transforming growth factor beta receptors | glomerulonephritis | Transforming growth factor beta | ALK tyrosine kinase receptor | HFL-1 | glomerulosclerosis | CD246 | Inhibitor | Cluster of differentiation 246 | R 268712 | UUO | Anaplastic lymphoma kinase (ALK) | R-268712 | inhibit | TGF-β | R268712 | TGF-beta/Smad | CKD | TGF-β Receptor | Anaplastic lymphoma kinase
相关产品: KRCA-0008 | SM 16 | Blu-782 | Alectinib | ALK-IN-1 | EML4-ALK kinase inhibitor 1 | Repotrectinib | Lorlatinib | AZ12601011 | N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
相关库: Anti-Liver Cancer Compound Library | Angiogenesis related Compound Library | Immuno-Oncology Compound Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | TGF-beta/Smad Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途