化合物ROC-325 T16777
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 1859141-26-6 | ¥238.00 | 询底价 |
1 mL | 1859141-26-6 | ¥592.00 | 询底价 |
500 mg | 1859141-26-6 | 面议 | 询底价 |
25 mg | 1859141-26-6 | ¥1,570.00 | 询底价 |
2 mg | 1859141-26-6 | ¥340.00 | 询底价 |
100 mg | 1859141-26-6 | ¥3,340.00 | 询底价 |
5 mg | 1859141-26-6 | ¥495.00 | 询底价 |
50 mg | 1859141-26-6 | ¥2,330.00 | 询底价 |
10 mg | 1859141-26-6 | ¥786.00 | 询底价 |
Product Introduction
Bioactivity
英文名: ROC-325
描述: ROC-325 是一种有效的口服活性自噬抑制剂,具有抗癌活性。 ROC-325 诱导肾细胞癌凋亡并表现出良好的特异性。
体外活性: ROC-325 (5 μM) leads to the formation of LC3B punctae and a robust increase in LC3B levels in both A498 and 786-0 RCC cells. ROC-325 promotes a dose-dependent increase in LC3B expression in a manner that correlated with a corresponding increase in the levels of p62 and cathepsin D. ROC-325 inhibits cells growth with IC50 values of 4.9 μM, 11 μM, 4.6 μM, 5.4 μM, 7.4 μM, 11 μM, 8.2 μM, 5.8 μM, 5.0 μM, 11 μM, 8.4 μM and 6.0 μM for A498, A549, CFPAC-1, COLO-205, DLD-1, IGROV-1, MCF-7, MiaPaCa-2, NCI-H69, PC-3, RL and UACC-62 cells, respectively. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux[1].
体内活性: In mice bearing 786-0 RCC xenografts, ROC-325 (25, 40, and 50 mg/kg; oral) leads to significant, dose-dependent inhibition of disease progression and inhibits autophagy in vivo[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL (59.64 mM)
H2O : 0.8 mg/mL (1.59 mM)
关键字: Apoptosis | anticancer | inhibit | ROC325 | ROC 325 | Autophagosomes | ROC-325 | cathepsin-D | lysosomes | oral | Autophagy | Inhibitor
相关产品: Chelidonine | Mezigdomide | Swainsonine | NVP-2 | TJ191 | STAT5-IN-2 | OTS514 | Triptonide | TAS6417 | ZM-447439
相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Autophagy Compound Library | Orally Active Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途