化合物Rotigaptide TFA T16790L

Product Introduction
Bioactivity


英文名: Rotigaptide TFA(355151-12-1 free base)

描述: Rotigaptide TFA(355151-12-1 free base) 是一种新型的 Cx43 特异性调节剂，是一种有效的 AAP。 Rotigaptide 可防止 Cx43 介导的间隙连接通讯的解偶联，并使急性代谢应激期间的细胞间通讯正常化。

体外活性: Rotigaptide TFA (100 nM; 24 hours) does not affect INS-1 cell apoptosis itself. Rotigaptide (100 nM; 24 hours) has a positive effect on the cycloheximide-mediated decrease in Cx43 protein levels in cultured neonatal ventricular myocytes. And it obviously decreases apoptosis in cytokine-exposed cells ~10% at IL-1b concentrations above 15 pg/ml in rat insulin-producing INS-1 cells [1][2].

体内活性: Rotigaptide TFA (intravenous administration; 300 mg/kg; single dose) treatment in mice and rats does not cause toxicity in either species. Rotigaptide (continuous intravenous infusion; 5-14 days) in rats (100 mg/kg) and dogs (10 mg/kg) is well tolerated and produces no compound-related effects or histological toxicological findings in escalating dose studies [3].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 7.32 mg/mL (10 mM)


关键字: Rotigaptide TFA(355151 12 1 free base) | Rotigaptide TFA(355151121 free base) | Rotigaptide TFA(355151-12-1 free base)

相关产品: Meclofenamic acid | Peptide5 TFA | Carbenoxolone disodium | Larazotide acetate | Danegaptide Hydrochloride | TAT-Gap19 acetate | Gap 27 | Gap19 | Gap 26 | Meclofenamic acid sodium

相关库: Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途