化合物SCH28080 T16865

Product Introduction
Bioactivity


英文名: SCH28080

描述: SCH28080 是一种可逆且具有 K+ 竞争性的胃 H+/K+-ATP 酶 (H+/K+-ATPase) 抑制剂，IC50 值为 20 nM (家兔微粒体膜)。SCH28080 在体内是有效的酸分泌抑制剂，具有抗溃疡活性、抗分泌和细胞保护活性。

体外活性: SCH28080 competitively hinders ATP hydrolysis stimulated by K+, with a Ki value of 0.12 μM.[1]SCH28080 effectively suppresses histamine-induced uptake of [14C]aminopyrine in isolated rabbit parietal cells, demonstrating an IC50 of 0.029 μM.[1]SCH28080 elicits a dose-dependent decrease in cell viability, with IC50 values of 22.9 µM and 15.3 µM following 2-hour and 24-hour treatments, respectively. And at concentration of 100 µM, cell viability drops below 10% as early as 2 hours.[2]SCH28080 induces apoptosis and exhibits cytotoxicity at higher doses.[2].SCH28080 also impedes insulin secretion by activating IK ATP and inhibiting L-type voltage-gated Ca2+ channels, ultimately reducing cell viability and induces apoptosis/necrosis in a dose-dependent manner.[2]

体内活性: SCH28080 (20 mg/kg; i.p.) effectively attenuates gastric ulcers induced by pylorus ligation in rats.[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 90.0 mg/mL (324.5 mM)


关键字: SCH-28080 | SCH 28080 | SCH28080

相关产品: Lasiodiplodin | Chebulinic acid | Clorsulon | Paederosidic acid methyl ester | (S)-PF-03716556 | Odoroside H | Ciclopirox olamine | Goniothalamin | Sudoterb free base | Dihydroisotanshinone I

相关库: Mitochondria-Targeted Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Exosome Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途