司替帕泛 T16874

Product Introduction
Bioactivity


英文名: Setipafant

描述: Setipafant is an antagonist of the platelet-activating factor.

体内活性: Pretreatment of the animals with one or other of the structurally unrelated PAF receptor antagonists, BN 52021 (10 mg/kg, i.p.) or Setipafant (1 mg/kg, i.p.) significantly decreases Dexamethasone-induced gastric damage. Animals are separated into six groups: U4, controls; S, sham-operated animals undergoing laparotomy; I4 and I9, ligation of the mesenteric vessels in the last ileal loop; IT4 and IT9, same procedure together with treatment with Setipafant (50 mg/kg) orally before and after surgery and intraperitoneally during surgery. Animals are killed at day 4 in groups U4, S, I4, and IT4 and on day 9 in groups I9 and IT9, with histological studies and mediator measurements taken. Macroscopic and histological lesions of the intestinal wall in groups I4, I9, IT4, and IT9 are similar to those of human neonatal necrotizing enterocolitis and do not vary according to the absence or the presence of Setipafant treatment. Peritoneal bands are significantly reduced in treated groups IT4 and IT9 as compared with untreated ones I4 and I9. Mucosal PAF levels in the terminal ileum are higher in group I4 than in groups U4 or I9. In the upper loop, mucosal PAF levels are comparable in all groups. An increase in stool PAF levels is observed only in group I9, whereas values comparable to those observed in controls are detected in other groups [1][2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: BN50727 | LAU 0901 | BN 50727 | Setipafant | LAU0901

司替帕泛 T16874信息由TargetMol中国为您提供，如您想了解更多关于司替帕泛 T16874报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途