化合物ST034307 T16938

Product Introduction
Bioactivity


英文名: ST034307

描述: ST034307 是一种选择性 adenylyl cyclase 1抑制剂，IC50值为 2.3 μM。

体外活性: ST034307 obviously inhibits the forskolin- or isoproterenol-stimulated AC1 activity in HEK cells stably expressing AC1. ST034307 significantly inhibits the Ca2+/calmodulin-stimulated cAMP accumulation in the hippocampal homogenates. ST034307 dose-dependently inhibits both the development and the maintenance of the MOR-mediated sensitization of AC1. ST034307 reveals selective inhibition of AC1 and potentiates AC8 activity to a nonsignificant small extent. ST034307 potentiates phorbol 12-myristate 13-acetate (PMA)-stimulated cAMP production by AC2. ST034307 has no significant effects on wild-type HEK cells [1].

体内活性: ST034307 在老鼠疼痛模型中展示了其止痛效力的估计中位有效剂量（E50）值为0.28 μg。ST034307（0.25 μg）在老鼠中引发了明显的CFA诱发的炎症疼痛缓解[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (167.81 mM)


关键字: Adenylate Cyclase | Inhibitor | ST-034307 | inhibit | ST034307 | ST 034307 | Adenylyl cyclase

相关产品: 2',5'-Dideoxyadenosine | NB001 | Forskolin | LRE1 | NKY80 | α-MSH | AC1-IN-1 | Wnt pathway inhibitor 3

相关库: Anti-Neurodegenerative Disease Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途