化合物 T16979 T16979
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 1373431-65-2 | ¥5,400.00 | 询底价 |
5 mg | 1373431-65-2 | ¥1,280.00 | 询底价 |
1 mL | 1373431-65-2 | ¥1,560.00 | 询底价 |
100 mg | 1373431-65-2 | ¥9,150.00 | 询底价 |
25 mg | 1373431-65-2 | ¥4,150.00 | 询底价 |
2 mg | 1373431-65-2 | ¥769.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Talazoparib tosylate
描述: Talazoparib tosylate is a novel and potent PARP1/2 (n IC50: 0.57 nM for PARP1).
体外活性: Talazoparib inhibits PARP1 and -2 to a similar extent (Kis: 1.20 and 0.85 nM, respectively). Talazoparib induces nuclear γ-H2AX foci at concentrations as low as 100 pM. Talazoparib has no effect on PARG activity at concentrations up to 1 μM. Talazoparib binds to PARP1 with a dissociation constant of 0.29 nM. Talazoparib selectively targets tumor cells with BRCA1, BRCA2, or PTEN gene defects with 20- to more than 200-fold greater potency than existing PARP1/2 inhibitors. Talazoparib targets tumor cells with homologous recombination gene defects. Tumor models that are either BRCA1-deficient or BRCA2-deficient are profoundly sensitive to Talazoparib. [1].
体内活性: Talazoparib is readily orally bioavailable, with more than 40% absolute oral bioavailability in rats when dosed in carboxymethyl cellulose. Talazoparib (p.o.) elicits remarkable antitumor activity; xenografted tumors that carry defects in DNA repair due to BRCA mutations or PTEN deficiency are profoundly sensitive to oral Talazoparib treatment at well-tolerated doses in mice [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 108 mg/mL (195.46 mM)
关键字: Talazoparib tosylate | Talazoparib Tosylate
相关产品: AZD-9574 | Lasiodin | Senaparib | RBN-3143 | 3-Aminobenzamide | Sageone | Ferruginol | 4-amino-1,8-Naphthalimide | Niraparib (R-enantiomer) | PARP1-IN-5 dihydrochloride
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途