化合物TCH-165 T17011

Product Introduction
Bioactivity


英文名: TCH-165

描述: TCH-165 是一种蛋白酶体组装的小分子调节剂，可增加游离 20S 水平，进而增强 IDP 蛋白水解。

体外活性: TCH-165, resulting in an increase in 20S levels.?The increase in the level of free 20S corresponds to enhanced proteolysis of IDPs, including α-synuclein, tau, ornithine decarboxylase, and c-Fos, but not structured proteins.?Clearance of ubiquitinated protein was largely maintained by single capped proteasome complexes (19S-20S), but accumulation occurs when all 19S capped proteasome complexes are depleted[1].

存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (83.93 mM)


关键字: Proteasome | tau | trypsin-like | 20S | IDPs | chymotrypsin-like | degradation | α-syn | inhibit | TCH 165 | caspase-like | TCH165 | assembly | TCH-165 | Inhibitor

相关产品: MG-132 | TPCK | Proteasome-IN-1 | Omarigliptin | Antitrypanosomal agent 15 | KZR-504 | Davelizomib | Bortezomib | N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride | Pepstatin

相关库: HIF-1 Signaling Pathway Compound Library | Bioactive Compounds Library Max | Ubiquitination Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途