化合物TPA 023 T17144

Product Introduction
Bioactivity


英文名: TPA 023

描述: TPA 023 是 GABAA α2/α3 亚型的特异性激动剂 (Ki = 0.19 - 0.41 nM)。

体内活性: TPA023 (0.7, 2.0, and 5 mg/kg, p.o.) blocks ketamine's cognitive-impairing ability but does not influence the behavioral symptoms of rhesus monkeys[1]. In rats, TPA023 (0.42 mg/kg; oral) displays good receptor occupancy and results in 50% occupancy of rat brain GABAA receptors, with the corresponding plasma concentration being 25 ng/mL. TPA023 (3 mg/kg p.o. in 0.5% methylcellulose) shows anxiolytic-like effect on rats. TPA023(10 mg/kg i.p.) is efficacious in the mouse pentylenetetrazole-induced seizure model, providing full seizure protection(84% occupancy), with the ED50 of 0.19-0.41 nM[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (126.44 mM)


关键字: inhibit | γ-Aminobutyric acid Receptor | Inhibitor | Gamma-aminobutyric acid Receptor | TPA-023 | GABA Receptor | TPA023 | TPA 023

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