α-倒捻子素 T1717

Product Introduction
Bioactivity


英文名: alpha-Mangostin

描述: alpha-Mangostin (Mangostin) 是有多种生物活性的膳食呫吨酮。它是一种IDH1突变体的抑制剂，Ki 值为 2.85 μM。

细胞实验: IDH1+/+ and IDH1
体外活性: Alpha-mangostin exhibits a selective inhibitory effect on IDH1-R132H, but not on IDH1. Alpha-mangostin competitively inhibits the binding of alpha-mangostin (α-KG) to IDH1-R132H. The structure–relationship study reveals that alpha-mangostin exhibits the strongest core inhibitor structure. Alpha-mangostin selectively promotes demethylation of 5-methylcytosine (5mC) and histone H3 trimethylated lysine residues in IDH1 (+/R132H) MCF10A cells[1]. Cell proliferation significantly decreases in a dose-dependent manner in the cells treated with alpha-mangostin. Alpha-mangostin also increases the levels of Bax (pro-apoptotic), cleaved caspase-3, cleaved caspase-9 and cleaved-poly(ADP-ribose) polymerase (PARP)[2]. Alpha-mangostin significantly inhibits light-induced degeneration of photoreceptors and 200 μM Water2-induced apoptosis of RPE cells. 200 μM Water2-induced generation of reactive oxygen species (ROS) and light-induced generation of malondialdehyde (MDA) are suppressed by alpha-mangostin[3].

体内活性: Alpha-mangostin reduces risk of liver fibrosis through the decrease in p53 expression as compared to the TAA_DMSO treatment. The serum levels of the liver enzymes AST and ALT after treatment with α-mangostin decrease as compared to DMSO alone[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (109.63 mM)


关键字: Fungal | inhibit | Inhibitor | alpha Mangostin | Apoptosis | alphaMangostin | Reactive Oxygen Species | alpha-Mangostin | Bacterial | a-Mangostin | Virus Protease

相关产品: S-allyl-L-cysteine | Pilaralisib analogue | 4-Hydroxybenzyl alcohol | CHM-1 | KH16 | AZD0156 | Ginsenoside Rh2 | ranaconitine | Picroside II | Larotrectinib

相关库: Anti-Prostate Cancer Compound Library | Pyroptosis Compound Library | Tobacco Monomer Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | Food as Medicine Compound Library | Antiparasitic Natural Product Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途