化合物UPGL00004 T17206

Product Introduction
Bioactivity


英文名: UPGL00004

描述: UPGL00004 是一种有效的谷氨酰胺酶 C (GAC) 抑制剂 ，其 IC50为29 nM。UPGL00004 对 GAC 的 Kd 为27 nM。UPGL00004 对高度侵袭性三阴性乳腺癌细胞系的增殖具有很强的抑制作用 。

体外活性: UPGL00004 inhibits MDA-MB-231, HS578T, and TSE cells (IC50s: 70, 129, and 262 nM, respectively).[1]

体内活性: In a triple-negative breast cancer patient-derived tumor graft model, the combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 112.5 mg/mL (210.4 mM)


关键字: UPGL00004 | UPGL 00004 | UPGL-00004

相关产品: GLS1 Inhibitor-7 | 6-Diazo-5-oxo-L-nor-Leucine | Telaglenastat | GLS1 Inhibitor-4 | BPTES | BJJF078 | Glutaminase C-IN-1 | GK921 | Sirpiglenastat | Glutaminase-IN-3

相关库: Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途