维卡布鲁替尼 T17220
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 1510829-06-7 | ¥8,160.00 | 询底价 |
5 mg | 1510829-06-7 | ¥1,930.00 | 询底价 |
1 mL | 1510829-06-7 | ¥2,260.00 | 询底价 |
25 mg | 1510829-06-7 | ¥4,490.00 | 询底价 |
50 mg | 1510829-06-7 | ¥5,920.00 | 询底价 |
10 mg | 1510829-06-7 | ¥2,830.00 | 询底价 |
1 mg | 1510829-06-7 | ¥786.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Vecabrutinib
描述: Vecabrutinib (SNS-062) (SNS-062) 是一种有效的,非共价的 BTK 和 ITK 抑制剂,Kd 值分别为 0.3 nM 和 2.2 nM。Vecabrutinib 对 ITK 的 IC50 值为 24 nM。
体外活性: Vecabrutinib is six times more potent than PCI-32765 and greater than 640 times more potent than acalabrutinib against C481S BTK. Vecabrutinib inhibits pBTK in human whole blood (average IC50: 50 nM). Vecabrutinib inhibits WT and C481S BTK with similar IC50s (pBTK IC50s: 2.9 nM and 4.4 nM for WT BTK and C481S BTK). In a recombinant kinase assay, IC50s of Vecabrutinib against WT BTK and C481S BTK are 4.6 nM and 1.1 nM. Vecabrutinib retains activity against the mutated BTK variant. Vecabrutinib demonstrates dose-dependent inhibition of BTK in primary patient CLL cells comparable to PCI-32765 via immunoblot for BTK phosphorylation. Vecabrutinib decreases the viability of primary CLL cells in the presence of HS5 stromal protection by 5.5% [1][2].
体内活性: Vecabrutinib在持续给药下具有良好的耐受性。在大鼠和犬中,Vecabrutinib展现出良好的口服生物利用度(%F ≥ 40%),并且具有5到6小时的终末半衰期[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 112.5 mg/mL (212.3 mM)
关键字: Vecabrutinib | SNS 062 | SNS062
相关产品: Tyrosine kinase inhibitor | GTP-14564 | Cerdulatinib | Beta-Hydroxyisovalerylshikonin | Gefitinib | Vidarabine | TAK-659 hydrochloride | NVP-BSK805 | AZ7550 | Larotinib
相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途