(R)-(-)-布洛芬 T17309

Product Introduction
Bioactivity


英文名: (R)-(-)-Ibuprofen

描述: (R)-(-)-Ibuprofen ((R)-Ibuprofen) 是 Ibuprofen 的 R 型异构体，对 COX 无作用，可以抑制 NF-κB 的活化；(R)-(-)-Ibuprofen 具有抗炎作用，可用于缓解疼痛的研究。

体外活性: (R)-(-)-Ibuprofen is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen inhibits NF-κB luciferase activity (IC50: 121.8 μM), weaker than that of S(+)-ibuprofen (IC50, 61.7 μM). (R)-(-)-Ibuprofen (1 μM) significantly decreases NF-κB activation and fully prevents NF-κB induction at 10 μM. Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF [1][2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (218.15 mM)


关键字: Ibuprofen

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相关库: Anti-Breast Cancer Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Compound Library | NF-κB Signaling Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Antidepressant Compound Library | Inhibitor Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library

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