化合物LY2584702 tosylate T1746

Product Introduction
Bioactivity


英文名: LY-2584702 tosylate salt

描述: LY-2584702 tosylate salt 是一种选择性的 ATP 竞争性 p70S6K 抑制剂，IC50为 4 nM，对S6K1的IC50为 2 nM，用于研究癌症治疗的试验。

体外活性: In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM. [1] LY2584702 has significant synergistic effects when combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus. [2]

体内活性: LY2584702 (12.5 mg/kg BID), demonstrates significant antitumor efficacy in both U87 mg glioblastoma and HCT116 colon carcinoma xenograft models. [1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 7 mg/mL(11.3 mM)


关键字: LY 2584702 | inhibit | S6K | LY2584702 | LY 2584702 Tosylate | LY-2584702 | Inhibitor | LY 2584702 tosylate salt | LY2584702 tosylate salt | LY2584702 Tosylate | LY-2584702 Tosylate | Ribosomal S6 Kinase (RSK)

相关产品: SL 0101-1 | LJI308 | A-443654 | BI-D1870 | Pluripotin | CHIR 98024 | Lenaldekar | Prexasertib dihydrochloride | CYC-116 | MBM-55S

相关库: Drug Repurposing Compound Library | Anti-Prostate Cancer Compound Library | Glutamine Metabolism Compound Library | Anti-Cancer Drug Library | Neuronal Differentiation Compound Library | Cancer Cell Differentiation Compound Library | Anti-Cancer Clinical Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途