化合物Mps1-IN-2 T1839

Product Introduction
Bioactivity


英文名: Mps1-IN-2

描述: Mps1-IN-2 是一种 ATP 竞争性Mps1/Plk1选择性双重抑制剂，对 Mps1 的IC50和Kd 值分别为 145 和 12 nM，对 Plk1 的Kd 值为 61 nM。

激酶实验: mTOR activity is assayed using LanthaScreen Kinase kit reagents. PI(3)K α, β, γ and δ activity are assayed using the PI(3)K HTRF assay kit. The concentration of INK128 necessary to achieve inhibition of enzyme activity by 50% (IC50) is calculated using concentrations ranging from 20 μM to 0.1 nM (12-point curve). IC50?values are determined using a nonlinear regression model.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 14.3 mg/mL (30 mM)


关键字: inhibit | Inhibitor | Monopolar spindle 1 | Mps1 | Mps1 IN 2 | Polo-like Kinase (PLK) | Mps1IN2 | Mps1-IN-2 | Mps-1-IN-2

相关产品: CCT251455 | NMS-P715 | S-trityl-L-Cysteine | Monastrol | Betamethasone 17-benzoate | GW406108X(Z/E) | BRD9876 | (S)-Monastrol | MPI-0479605 | UMK57

相关库: Cell Cycle Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Kinase Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途