化合物 T18846 T18846
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
2 mg | 2378261-80-2 | ¥270.00 | 询底价 |
Product Introduction
Bioactivity
英文名: THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
描述: THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a polyethylene glycol (PEG) based PROteolysis TArgeting Chimera (PROTAC) linker, employed for the synthesis of PROTAC K-Ras Degrader-1, as documented in reference [1].
体外活性: PROTAC K-Ras Degrader-1 is potent?K-Ras?degrader based?PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: THPPEG4Pyrrolidine(NBoc)CH2OH | THP-PEG4-Pyrrolidine(N-Boc)-CH2OH | THP-PEG-4-Pyrrolidine(N-Boc)-CH2OH | THP PEG4 Pyrrolidine(N Boc) CH2OH
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途