AkaLumine盐酸盐 T18914

Product Introduction
Bioactivity


英文名: AkaLumine hydrochloride

描述: AkaLumine hydrochloride 是一种荧光素类似物，对重组荧光蛋白的 Km 值为 2.06 μM。

体外活性: In both LLC/luc and MDA-MB-231/Luc cells exposed to AkaLumine hydrochloride, the signal achieves its peak intensity at lower concentrations (starting from 2.5 μM). Conversely, the bioluminescence produced by D-luciferin and CycLuc1 exhibits a continuous rise with increasing concentrations, without reaching an apparent saturation point, even at the highest concentration of 250 μM.[1]

体内活性: AkaLumine hydrochloride-treated mice 15 min after intravenous injection of LLC/luc cells at the dose of 5 mM, exhibit a 3.3-fold increase in detection sensitivity of disseminated cancer cells in the lung compared with the experimental control group. In the inverse order at an 8 h interval. AkaLumine hydrochloride displays about a fourfold increase in signals from lung metastasis compared with the experimental control group.[1]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45.0 mg/mL (132.8 mM)
H2O : 45.0 mg/mL (132.8 mM);


关键字: 1176235-08-7 free base | 1176235-08-7 | AkaLumine Hydrochloride

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途