蓝色染料 T19049
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 12236-82-7 | ¥4,450.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Procion Blue HB
描述: Procion Blue HB is an antagonist of purinergic.
体外活性: Reactive Blue 2 is used as an ATP receptor antagonist and induces Ca2+ oscillations in HeLa cells. Reactive Blue 2 enhances a Ca2+ response to histamine that is linked to the PLC cascade. Reactive Blue 2 may activate the PLC cascade in an extracellular Ca2+-dependent manner and induce Ca2+ oscillations [1]. The application of Reactive Blue 2 increases K+ secretion in a dose-dependent manner. Reactive Blue 2 has antagonistic activities at P2Y4, and the antagonist potency at P2Y4 paralleled the potency of K+ secretion [2]. The anthraquinone dye reactive blue 2 is found to be a potent inhibitor of a protein kinase isolated and purified from thylakoids. The mode of inhibition is noncompetitive, with a Ki of 8 μM for the membrane-bound kinase, and 6 μM for the purified kinase. The inhibitor does not modify the substrate preference of the endogenous kinase and could be removed from the membrane by washing[3]. Reactive Blue 2 selectively inhibits responses mediated via the P2ypurinoceptor, at least within a limited concentration range. In preparations where the tone has been raised with ATP, noradrenaline, and 2-methylthio ATP, but not α,β-methylene ATP, produces relaxations of the vessel. These relaxations are inhibited in the presence of reactive blue 2 [4]. Reactive blue 2 (0.3-10 μM) blocks the ATP-induced oscillation in a concentration-dependent manner [5].
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 10 mg/mL (12.92 mM)
DMSO : 110 mg/mL (142.09 mM)
关键字: Procion Blue HB
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