硫酸乙酰肝素 T19355

Product Introduction
Bioactivity


英文名: Heparan Sulfate

描述: Heparan sulfate 是一种复杂的线性多糖。Heparan sulfate 作为硫酸乙酰肝素蛋白聚糖的一部分出现，在细胞外基质和细胞表面表达丰富。

体外活性: Heparan sulfate interacts with numerous proteins, including growth factors, morphogens, and adhesion molecules, and thereby regulates important developmental processes in invertebrates and vertebrates. Heparan sulfate chains regulate developmental signaling by acting as co-factors through a variety of mechanisms that include but are not limited to the maintenance of morphogen gradients and co-receptor functions [1]. Heparan sulfate proteoglycans can act as receptors for proteases and protease inhibitors regulating their spatial distribution and activity. Membrane Heparan sulfate proteoglycans act as coreceptors for various tyrosine kinase-type growth factor receptors, lowering their activation threshold or changing the duration of signaling reactions [2]. Heparan sulfate influences the binding affinity of intestinal epithelium cells to Wnt, thereby promoting activation of canonical Wnt signaling and facilitating the regeneration of small intestinal crypts after epithelial injury [3].

体内活性: FGF-2/FGFR system is involved in the regulation of astrocytic reactivity and/or proliferation in the brain and its action is potentiated by heparan sulfate [5]. Digestion of heparan sulfate impairs context discrimination in a fear conditioning paradigm and oscillatory network activity in the low theta band after fear conditioning. Thus, heparan sulfate maintains neuronal excitability and, as a consequence, support synaptic plasticity and learning [4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 100 mg/mL


关键字: Fibroblast growth factor receptor | Wnt | FGFR | Inhibitor | Endogenous Metabolite | Heparan Sulfate | Heparan | inhibit

相关产品: PD168393 | Dovitinib Dilactic Acid | PHA-680632 | Vofatamab | FGFR2-IN-1 | FGFR-IN-11 | S6K2-IN-1 | SSR128129E | Brivanib | Tyrphostin AG1296

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