羟丙甲纤维素 T19368

Product Introduction
Bioactivity


英文名: Hypromellose

描述: Hypromellose (HPMC) 是一种水溶性的亲水性非离子纤维素醚。

体外活性: Hypromellose (hydroxypropylmethylcellulose) has been used in sustained-release pharmaceutical products for many years. These polymers hydrate on contact with water to produce a viscous gel barrier within and surrounding the tablet when used in matrix tablets. The properties of hypromellose that affect the rate of drug release include the rate of diffusion of water into the dry polymer, the rate of hypromellose hydration and gel formation, the viscosity of the hydrated hypromellose, and rate of hypromellose gel erosion [2]. Hypromellose provides the release of a drug in a controlled manner, effectively increasing the duration of release of a drug to prolong its therapeutic effect [1].

体内活性: Punctal occlusion using hypromellose 2% is a low-cost and safe additional treatment for dry eye. Fluorescein and rose bengal staining tests show that there was a significant reduction in signs after occlusion using hypromellose [3]. Hypromellose is effective in improving blood glucose metabolism and suppressing oxidative stress in mice fed with a high-fat diet. The antihyperglycemic and antioxidative effects of hypromellose could be partly attributed to the regulation of hepatic glucose-regulating enzyme activities and activation of the hepatic and erythrocyte antioxidant enzymes [4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12.61 mg/mL (10 mM)
H2O : 9 mg/mL


关键字: Celacol HPM5000 | inhibit | Hypromellose | Inhibitor | Celacol HPM-5000

相关库: Inactive Ingredient Library | Food Additive Library | Human Metabolite Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途