链球菌溶血素 O T19565

Product Introduction
Bioactivity


英文名: Streptolysin O

描述: Streptolysin O causes both lysis of cells and cardiotoxicity. Streptolysin O is widely used for the controlled permeabilization of cell membranes. Streptolysin O exists in two forms, a reduced active state and an oxidized reversibly inactive state .

体外活性: When streptococci secrete streptococcal hemolysin O, it is in an active state, but it will quickly oxidize into a reversible inactive state and form disulfide bonds[2]. Streptolysin O is a secreted virulence factor of GAS that induces apoptosis in neutrophils and macrophages at later time points (~4 h). Streptolysin O induces eukaryotic cell lysis in a cholesterol-dependent manner, is highly upregulated in the GAS M1T1 clone during bloodstream dissemination. Streptolysin O is known to promote Group A Streptococcus (GAS) resistance to phagocytic clearance by neutrophils, a critical first element of host defense against invasive bacterial infection[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Streptolysin O

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