盐酸丁双胍 T20029

Product Introduction
Bioactivity


英文名: Buformin hydrochloride

描述: Buformin hydrochloride (NSC-528218) 是一种有效的 AMPK 激活剂，是一种双胍类的口服抗糖尿病药物。Buformin 延缓胃肠道对葡萄糖的吸收，增加胰岛素敏感性和葡萄糖对细胞的吸收，并抑制肝脏对葡萄糖的合成。Buformin 也具有抗癌活性，可用于各种癌症研究。

体外活性: Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC50 values of 246.7 μM and ?98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively[1].Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells[1].Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells[1].

体内活性: Buformin hydrochloride (oral administation; 7.6?mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and?hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/ml (309.79 mM)


关键字: agent | Type II diabete | inhibit | Buformin hydrochloride | Inhibitor | SKBR3 | cervical cancer | breast cancer | AMPK | biguanide analog | BT474 | 1-Butylbiguanide | antidiabetic | AMP-activated protein kinase | Buformin | Buformin Hydrochloride

相关产品: TMPA | Annaosanchun | MRT67307 HCl (1190378-57-4(free base)) | HTH-01-015 | Dorsomorphin | Adenosine monophosphate | Karanjin | YLF-466D | Kazinol B | PF-06409577

相关库: Drug Repurposing Compound Library | PI3K-AKT-mTOR Compound Library | Anti-Breast Cancer Compound Library | FDA-Approved Kinase Inhibitor Library | Anti-Cancer Drug Library | Kinase Inhibitor Library | Epigenetics Compound Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途