化合物WS3 T2055

Product Introduction
Bioactivity


英文名: WS3

描述: WS3 是一种可促进鼠和人原代胰岛的胰腺 β 细胞增殖的增殖分子。它可用于研究 I 型糖尿病。

细胞实验: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. (Only for Reference)

体内活性: 在小鼠β细胞系R7T1中,WS3诱导细胞增殖（EC50=0.074 μM）。在原代胚胎和成人视网膜色素上皮细胞中,WS3可逆诱导细胞发生增殖。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 93 mg/mL (163.3 mM)
Ethanol : 74 mg/mL (129.9 mM)


关键字: insulin | pancreatic | pigment | proliferation | epithelial | β cell | Inhibitor | R7T1 | diabete | RPE | WS3 | inhibit | WS 3 | retinal | WS-3

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相关库: Anti-Aging Compound Library | Anti-Prostate Cancer Compound Library | HIF-1 Signaling Pathway Compound Library | Anti-Liver Cancer Compound Library | Membrane Protein-targeted Compound Library | Anti-Lung Cancer Compound Library | Kinase Inhibitor Library | Anti-Diabetic Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Pancreatic Cancer Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途