维拉帕米 T20656

Product Introduction
Bioactivity


英文名: Verapamil

描述: Verapamil (CP-16533-1) 是一种钙通道阻滞剂，是一种口服有效的 P-gp 抑制剂。Verapamil 抑制 CYP3A4，可用于治疗高血压、心律失常和心绞痛的研究。

体外活性: Verapamil 在浓度依赖的方式下抑制 TR-iBRB2 细胞吸收 EverFluor FL Verapamil (EFV)，其 IC50 值为 98.0 μM[1]。

体内活性: Verapamil (1 mg/kg;i.v.) significantly decreases the incidence of ventricular arrhythmias including premature ventricular contractions (PVC), ventricular tachycardia (VT) and ventricular fibrillation (VF) for 45-min coronary artery occlusion. Total arrhythmia scores are significantly increased when the heart is subjected to ischemia. Verapamil (1 mg/kg) significantly prevents the enhancement of total arrhythmia scores induced by ischemia[3]. Verapamil(oral) is useful for the prophylaxis of atrioventricular reentry tachycardia, and also in modulating the atrioventricular nodal response in atrial fibrillation[4].

存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (98.99 mM)


关键字: inhibit | Pgp | antiarrhythmic | CYP3A4 | Cytochrome P450 | Palbociclib | CYPs | pressure | ABCB1 | Calcium Channel | P-gp | angina | Multidrug resistance protein 1 | Ca2+ channels | lysosomotropic | MDR1 | Ca channels | Verapamil | Cluster of differentiation 243 | high | NSC135784 | Inhibitor | P-glycoprotein | CD243 | blood

相关产品: Topiroxostat | Casopitant mesylate | Furafylline | Apigenin | Dronedarone | Avasimibe | Chlorzoxazone | Demethyleneberberine | Atazanavir | TMS

相关库: Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途