化合物NS 11394 T2067
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 951650-22-9 | ¥997.00 | 询底价 |
50 mg | 951650-22-9 | ¥3,730.00 | 询底价 |
100 mg | 951650-22-9 | ¥5,430.00 | 询底价 |
5 mg | 951650-22-9 | ¥779.00 | 询底价 |
1 mg | 951650-22-9 | ¥329.00 | 询底价 |
25 mg | 951650-22-9 | ¥2,260.00 | 询底价 |
2 mg | 951650-22-9 | ¥478.00 | 询底价 |
10 mg | 951650-22-9 | ¥1,230.00 | 询底价 |
Product Introduction
Bioactivity
英文名: NS11394
描述: NS11394 是可口服GABAA 的阳性变构调节剂 (PAM),Ki 值为 0.5 nM。它对GABAA 的选择性依次为 α5、α3、α2 和α1 受体,具有抗炎和抗焦虑活性。
激酶实验: Inhibition of FLT3 autophosphorylation: To measure inhibition of FLT3 autophosphorylation, MV4-11 or RS4;11 cells are cultured in low serum media (0.5% FBS) overnight and seeded at a density of 400 000 cells per well in a 96-well plate the following day. The cells are incubated with different concentrations of AC220 for 2 hours at 37 °C. To induce FLT3 autophosphorylation in RS4;11 cells, 100 ng/mL FLT3 ligand is added for 15 minutes after the 2-hour AC220 incubation. Cell lysates are prepared and incubated in 96-well plates precoated with a total FLT3 capture antibody. The coated plates are incubated with either a biotinylated antibody against FLT3 to detect total FLT3 or an antibody against phosphotyrosines to detect FLT3 autophosphorylation. In both cases, a SULFO-tagged streptavidin secondary antibody is used for electrochemiluminescence detection on the Meso Scale Discovery platform. The concentration of AC220 that inhibits FLT3-ITD or TLT3-WT autophosphorylation by 50% represents IC50 value
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL (169.77 mM)
关键字: Inhibitor | Anxiety | cord | γ-Aminobutyric acid Receptor | neuropathi | electrophysiological | Freund’s | inhibit | Complete | pain | Gamma-aminobutyric acid Receptor | adjuvant | inflammatory | pinal | NS-11394 | NS11394 | GABA Receptor
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途