化合物XRP44X T20759

Product Introduction
Bioactivity


英文名: XRP44X

描述: XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。

体外活性: XRP44X is an indirect inhibitor of Net phosphorylation that acts upstream from Erk-1/2 activation. XRP44X inhibits luciferase activity with the IC50 of～10 nM[1].XRP44X (10 nM) inhibits cell growth of HUVEC, NIH3T3, HCT-116, and NIH3T3–Ki-Ras cells[1].XRP44X (100 nM) inhibits phosphorylation of Mek-1/2 and Raf-1[1].

体内活性: XRP44X具有治疗难治性哮喘的潜力[1]。作为Ras/Erk激活转录因子Elk3的抑制剂，XRP44X在裸鼠中抑制肿瘤生长和转移。通过抑制肿瘤生长及裸鼠中的转移形成，XRP44X显示了其对抗肿瘤及转移的潜在效用[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 36.67 mg/ml (96.27 mM)


关键字: Ras/Erk activation | inhibit | Ras-induced transcription | Ras | XRP44X | refractory asthma | microtubules | Inhibitor

相关产品: CCG-100602 | Oncrasin-1 | ML-210 | ML141 | CCG-222740 | KRAS inhibitor-7 | Antineoplaston A10 | Rac1-IN-3 | ARS-1323 | RMC-7977

相关库: Anti-Prostate Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Microtubule-Targeted Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | GPCR Compound Library | Kinase Inhibitor Library | Anti-Colorectal Cancer Compound Library | Anti-Obesity Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途