盐酸普奈洛尔 T20898

Product Introduction
Bioactivity


英文名: (R)-Propranolol hydrochloride

描述: (R)-Propranolol hydrochloride (Dexpropranolol hydrochloride) 是一种抗肾上腺素受体拮抗剂，是一种普萘洛尔的活性较低的对映体。Dexpropranolol 是一种非选择性的β-adrenergic receptor 拮抗剂，对 β1AR 和 β2AR 具有高亲和力。

体内活性: Both isomers of propranolol are capable of preventing adrenaline-induced cardiac arrhythmias in cats anaesthetized with halothane and reversing ventricular tachycardia caused by ouabain in anaesthetized cats and dogs, but the dose of (-)-propranolol is significantly smaller than that of (+)-propranolol ((R)-Propranolol) in both species[4]. Administration of 10 mg/kg (R)-Propranolol hydrochloride has no antagonistic activity in rats, the cardiac responses to isoprenaline of rats can be blocked by probably much less than 1/100th of that of the (-) isomer in this preparation[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 14.79 mg/mL (50 mM)
DMSO : 60 mg/ml (202.84 mM)


关键字: Inhibitor | enantiomer | Propranolol | Beta Receptor | (R)-Propranolol | Adrenergic Receptor | Dexpropranolol Hydrochloride | β-adrenoceptor | cardiac arrhythmias | (R)Propranolol hydrochloride | (R) Propranolol hydrochloride | inhibit | Propranolol Hydrochloride

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相关库: Adrenergic Receptor-Targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Alzheimer's Disease Compound Library | Bioactive Compound Library

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