化合物FH1 T2102
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
200 mg | 2719-05-3 | ¥3,675.00 | 询底价 |
1 mL | 2719-05-3 | ¥456.00 | 询底价 |
100 mg | 2719-05-3 | ¥2,683.00 | 询底价 |
50 mg | 2719-05-3 | ¥1,497.00 | 询底价 |
10 mg | 2719-05-3 | ¥415.00 | 询底价 |
5 mg | 2719-05-3 | ¥255.00 | 询底价 |
25 mg | 2719-05-3 | ¥852.00 | 询底价 |
Product Introduction
Bioactivity
英文名: FH1
描述: FH1 (NSC-12407) 可提高肝细胞功能,促进诱导多能干 (iPS) 衍生的肝细胞向更成熟的表型分化,并促使分化良好的肝细胞样细胞 (iHeps) 培养物的成熟。
激酶实验: Affinity determination: Binding affinities (Ki or IC50) of ABT-263 against different isoforms of Bcl-2 family are determined with competitive fluorescence polarization assays. The following peptide probe/protein pairs are used: f-bad (1 nM) and Bcl-xL (6 nM), f-Bax (1 nM) and Bcl-2 (10 nM), f-Bax (1 nM) and Bcl-w (40 nM), f-Noxa (2 nM) and Mcl-1 (40 nM), and f-Bax (1 nM) and Bcl-2-A1 (15 nM). Binding affinities for Bcl-xL are also determined using a time-resolved fluorescence resonance energy transfer assay. Bcl-xL (1 nM, His tagged) is mixed with 200 nM f-Bak, 1 nM Tb-labeled anti-His antibody, and ABT-263 at room temperature for 30 min. Fluorescence is measured on an Envision plate reader using a 340/35 nm excitation filter and 520/525 (f-Bak) and 495/510 nm (Tb-labeled anti-His antibody) emission filters.
体内活性: 在肝细胞中,FH1(BRD-K4477)促进分化完整的iHeps成熟,增强细胞功能。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 4.62 mg/mL (16.35 mM)
关键字: hHNF4α | IPS | hALB | FH-1 | iPSC | BRD-K-4477 | BRD-K 4477 | FH 1 | FH1 | inhibit | Inhibitor | hNTCP | hRXR | NSC12407 | NSC-12407
相关库: Bioactive Compounds Library Max | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途