曲伏前列素酸 T21224

Product Introduction
Bioactivity


英文名: (+)-Fluprostenol

描述: (+)-Fluprostenol (AL-5848) 是前列腺素 F2 α 的类似物，是一种前列腺素 F2α 受体 PTGFR 激动剂，可降低输卵管糖蛋白 1 (OVGP1) 的表达。

体内活性: (+)-Fluprostenol(s.c. to rats on day 18 of pregnancy) increased cervical creep, or softness, by the following day. Doses of (+)-Fluprostenol 100-fold larger were necessary to increase uterine contractions. (+)-Fluprostenol produced falls in serum progesterone concentrations, increases in 20 alpha-dihydroprogesterone concentrations, no changes in oestradiol or relaxin concentrations and a reduction in the ovarian human chorionic gonadotrophin binding capacity in vitro. (+)-Fluprostenol was less potent in inducing cervical softness when administered per vaginam, and a dose which produced softening in pregnant rats was ineffective in ovariectomized steroid-maintained pregnant or pro-oestrous rats[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 325 mg/mL (708.88 mM)


关键字: AL 5848 | PTGER2 | Oviductal glycoprotein 1 | Fluprostenol, | (+) Fluprostenol | inhibit | Fluprostenol | (+)Fluprostenol | OVGP1 | Inhibitor | (+)-Fluprostenol | AL5848

相关产品: Prostaglandin F2α 1,11-lactone | Capillarisin | Tebufelone | Anisotropine Methylbromide | NXT-10796 | BI-671800 | Rutin | Latanoprost | Carboprost | Vedaprofen

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途