化合物UNC 569 hydrochloride T21302L

Product Introduction
Bioactivity


英文名: UNC 569 hydrochloride

描述: UNC 569 hydrochloride 是一种可逆的 ATP 竞争性 Mer 抑制剂，IC50 为 2.9 nM，Ki 为 4.3 nM。 UNC 569 hydrochloride 抑制 Axl 和 Tyro3，IC50 分别为 37 nM 和 48 nM。 UNC 569 hydrochloride 可用于关于急性淋巴细胞白血病和非典型畸胎样/横纹肌样肿瘤的研究。

体外活性: UNC 569 hydrochloride inhibits Mer phosphorylation levels with IC50 values of 141 nM and 193 nM in human B-ALL 697 and Jurkat cell lines, respectively. UNC 569 hydrochloride (1 µM) treatment effectively inhibits the activation of Mer and downstream signaling, including the PI3K/AKT and MAPK/ERK pathways. In ALL cell lines, UNC 569 hydrochloride (0.4 -2 µM) induces apoptosis and increases the levels of cleaved Caspase 3 and cleaved PARP[1].

体内活性: In Leukemic zebrafish, UNC 569 hydrochloride (4 µM) induces more than 50% reduction in tumor burden compared with vehicle- and mock-treated fish[1]. UNC 569 hydrochloride has low systemic clearance (19.5 mL/min/kg), high volume of distribution (Vss of 5.83 L/kg), and good oral bioavailability (57%)[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.61 mg/mL (8.34 mM)


关键字: UNC 569 hydrochloride | 1350547-65-7 Free base | 1350547-65-7 | UNC 569 Hydrochloride | UNC-569 Hydrochloride | UNC569 Hydrochloride

相关产品: AXL-IN-14 | Dubermatinib | Ningetinib | UNC2250 | R916562 | Cabozantinib | Gilteritinib hemifumarate | LDC1267 | Gilteritinib | S49076

相关库: Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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