化合物U0126 T21332
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 109511-58-2 | ¥3,740.00 | 询底价 |
1 mg | 109511-58-2 | ¥770.00 | 询底价 |
25 mg | 109511-58-2 | ¥6,540.00 | 询底价 |
5 mg | 109511-58-2 | ¥1,980.00 | 询底价 |
Product Introduction
Bioactivity
英文名: U0126
描述: U0126 是一种有效的特异性非竞争性 MAP 激酶抑制剂,抑制 MEK-1 和 MEK-2,IC50 值分别为 0.07 和 0.06 μM。 U0126 抑制自噬和线粒体自噬。
体外活性: Rat hepatocarcinoma cells (FAO) stimulated by fetal calf serum (FCS) exhibits a significant proportion in S phase (32.62%) whereas U0126 strongly decreases the proportion of cells in S phase (9.92%) and increases the proportion of cells in G0-G1 phase and to a lesser extent in G2/M[1]. U0126 efficiently reduces progeny virus titers of all tested strains in A549 cells. While nM concentrations of U0126 are efficient to reduce H1N1v and H5N1 (MB1), μM concentrations of U0126 are required to reduce the virus titer of H5N1 (GSB) and H7N7. The EC50 values for U0126-EtOH against H1N1v are 1.2 μM in A549 cells and 74.7 μM in MDCKII cells[2].
体内活性: In mice, U0126-EtOH (U0126; i.p., 10.5 mg/kg) inhibits tumor growth with a 60-70% reduction 9 days after injection and thereafter[1]. After treatment with U0126-EtOH(U0126; i.p., 30 mg/kg), the vasoconstriction to S6c is markedly reduced in rats[3].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : Soluble
H2O : Soluble
关键字: MAP2K | inhibit | Inhibitor | Autophagy | U0126 | Mitophagy | Mitochondrial Autophagy | MEK | Influenza Virus | MAPKK | Mitogen-activated protein kinase kinase
相关产品: D-glutamine | Vorinostat | Salicylic acid | Quinacrine dihydrochloride | Ruxolitinib phosphate | Olaparib | Etoposide | Aspirin | Ruxolitinib | Metformin
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途