佛手柑内酯 T2143
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 484-20-8 | ¥298.00 | 询底价 |
1 mL | 484-20-8 | ¥250.00 | 询底价 |
500 mg | 484-20-8 | ¥690.00 | 询底价 |
50 mg | 484-20-8 | ¥212.00 | 询底价 |
1 g | 484-20-8 | ¥927.00 | 询底价 |
5 g | 484-20-8 | ¥3,690.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Bergapten
描述: Bergapten (5-Methoxypsoralen) 是白芷中的一种香豆素,也是一种补骨脂素,可抑制细胞复制。
细胞实验: 5-Methoxypsoralen (5-MOP) is dissolved in DMSO and stored, and then diluted with appropriate medium (final DMSO <0.1%) before use[1]. The human colon adenocarcinoma cell line (COLO 205, from a 70-year-old male Caucasian) sre placed into 75-cm2 tissue culture flasks and grown in RPMI1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. The human stomach adenocarcinoma cell line are placed into 75-cm2 tissue culture flasks and grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. SC-M1 and COLO 205 cells are treated with different concentrations of 5-MOP (0.05, 0.5, 5, 10, 25 and 50 mM) and incubated for 72 h for the dose-effect study of 5-MOP on NAT activity. To determine the time-course effect of 0.5 mM 5-MOP on NAT activity, the cells are incubated at 37AC and harvested at 12, 24, 48 and 72 h, respectively. 5-MOP is dissolved in DMSO and the final concentration of vehicle is <0.1%. Only DMSO (solvent) is added for the control regimen[1].
体外活性: 在对乙酰氨基酚(APAP)诱导的C57BL / 6J小鼠中,Bergapten能够发挥抗氧化活性,改善肝毒性.
体内活性: 在乳腺癌他莫昔芬敏感和耐药细胞中,Bergapten能够消除ERα,重新调整靶向ERα的膜信号,促进细胞有丝分裂的潜力。
存储条件: keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 20 mg/mL (92.51 mM)
关键字: Bergapten | inhibit | Inhibitor | Autophagy | CYPs | Cytochrome P450
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相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Metabolism Disease Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途