软木肟酸 T21505
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 38937-66-5 | ¥128.00 | 询底价 |
1 mL | 38937-66-5 | ¥99.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Suberoyl bis-hydroxamic acid
描述: Suberoyl bis-hydroxamic acid (SBHA) 是一种竞争性且可透过细胞的HDAC1和HDAC3抑制剂,ID50值分别为 0.25 μM 和 0.30 μM。它使肿瘤细胞易于凋亡并促进线粒体凋亡途径,可研究甲状腺髓样癌。
体外活性: In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: H2O : 8.16 mg/mL (40 mM)
DMSO : 49 mg/mL (239.93 mM)
关键字: MTC | inhibit | Histone deacetylases | Malignant | carcinoma | neoplastic disease | Suberoyl bis-hydroxamic acid | neuroendocrine malignancy | neoplasia | mesothelioma | Apoptosis | Suberoyl bishydroxamic acid | thyroid | Inhibitor | Medullary | Suberoyl bis hydroxamic acid | HDAC
相关产品: Ceranib-2 | Trolox | MS1943 | Atractylenolide II | Rhosin hydrochloride | PTC-028 | PYR-41 | Samuraciclib hydrochloride | Lorlatinib | EI1
相关库: Anti-Breast Cancer Compound Library | Mitochondria-Targeted Compound Library | NF-κB Signaling Compound Library | Inhibitor Library | Epigenetics Compound Library | DNA Damage & Repair Compound Library | Apoptosis Compound Library | Reprogramming Compound Library | Bioactive Compound Library | Chromatin Modification Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途