MMP-2/MMP-9 抑制剂I T21512

Product Introduction
Bioactivity


英文名: MMP-2/MMP-9 Inhibitor I

描述: MMP-2/MMP-9-IN-1 是一种有效的、具有高选择性和可口服的 IV 型胶原酶 (MMP-9和MMP-2) 抑制剂，对 MMP-9 和 MMP-2具有抑制作用， IC50分别为 0.24 和 0.3 1μM。MMP-2/MMP-9-IN-1 在肿瘤生长和转移的动物模型中展现出口服活性，可用于研究癌症。

体外活性: MMP-2/MMP-9 inhibitor I was identified as a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 with IC50 values of 310 and 240 nM, respectively. MMP-2/MMP-9 inhibitor I acted by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I was found to be able to block MMP-2/MMP-9-dependent invasion in cell culture model.[1]

体内活性: Both hydroxamic acid and carboxylic acid analogs of MMP-2/MMP-9 inhibitor I were evaluated for their inhibitory activities in animal cancer models. Results showed that lung colonization of Lewis lung carcinoma cells was suppressed by these inhibitors significantly. In addition, antitumor activity was also observed in the human lung cancer model. Ma44 cells growed as a solid tumor on the peritoneum after being implanted ip, and mice bearing Ma44 eventually died within 3 to 4 weeks. Daily oral administration of compound 5l led to prolonged survival of Ma44-bearing mice.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 180.0 mg/mL (471.9 mM)


关键字: MMP 2/MMP 9 Inhibitor I | MMP-2/MMP-9 Inhibitor I | MMP2/MMP9 Inhibitor I

相关产品: ND-322 HCl | 2-Methoxystypandrone | PF-00356231 hydrochloride | (-)-Epigallocatechin | Andecaliximab | Xanthyletin | Chondroitin sulfate | GI254023X | Bacoside A | Cedrelone

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Highly Selective Inhibitor Library | Protease Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途