不对称二甲基精氨酸二盐酸盐 T21546
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 220805-22-1 | ¥463.00 | 询底价 |
5 mg | 220805-22-1 | ¥359.00 | 询底价 |
1 mg | 220805-22-1 | ¥169.00 | 询底价 |
10 mg | 220805-22-1 | ¥517.00 | 询底价 |
50 mg | 220805-22-1 | 面议 | 询底价 |
Product Introduction
Bioactivity
英文名: NG,NG-dimethyl-L-Arginine dihydrochloride
描述: NG,NG-dimethyl-L-Arginine dihydrochloride 是一种内源性一氧化氮合酶抑制剂。由 L-精氨酸合成的一氧化氮 (NO) 有助于调节血压和宿主防御。
体外活性: NG,NG-dimethyl-L-Arginine (ADMA) was found to be able to inhibit macrophage and vascular NO synthase. When added to a cytosolic preparation of macrophage NO synthase, ADMA could cause dose-dependent inhibition of NO formation. In the presence of added arginine, ADMA could inhibited NO synthesis and the inhibitory effects of ADMA were prevented by addition of L-arginine so that the rate of NO synthesis did not significantly differ from control values [1].
体内活性: Animal study showed that the injection of 1-30 mg/kg ADMA into 3 anaesthetised guineapigs could cause dose-dependent increases in mean arterial blood pressure. Moreover, during continuous infusion of ADMA, which caused plasma ADMA concentrations to rise approximately 9-fold, the systolic blood pressure was raised by nearly 15 % [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: Ethanol : 11 mg/mL (39.97 mM)
DMSO : 7mg/mL (25.43 mM)
H2O : 14mg/mL (50.87 mM)
关键字: NG,NG dimethyl L Arginine dihydrochloride | NG,NG-dimethyl-L-Arginine Dihydrochloride | NG,NG-dimethyl-L-Arginine | NG,NGdimethylLArginine dihydrochloride
相关产品: Dehydrotrametenolic acid | Grossamide | Irisflorentin | Asymmetric dimethylarginine | Multiflorin B | 5-Hydroxy-7,8-dimethoxyflavanone | Kadsulignan H | Glabrol | 5,7,8-Trimethoxyflavone | 2,4-Diamino-6-hydroxypyrimidine
相关库: Bioactive Compounds Library Max | Inhibitor Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途