OTSSP 167 盐酸盐 T21559

Product Introduction
Bioactivity


英文名: OTSSP167 hydrochloride

描述: OTSSP167 hydrochloride 是一种高效的，ATP 竞争性的MELK 抑制剂，其 IC50=0.41 nM。

体外活性: OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 33 mg/mL (63 mM)
H2O : 7.14 mg/mL (13.63 mM)


关键字: OTSSP167 Hydrochloride | OTSSP-167 | OTSSP 167 | OTSSP167 | OTSSP-167 Hydrochloride | OTSSP167 hydrochloride | MELK | OTSSP-167 hydrochloride | Maternal embryonic leucine zipper kinase | inhibit | OTS167 | OTSSP 167 Hydrochloride | OTS-167 | OTS 167 | Inhibitor

相关产品: JTV-519 hemifumarate | HTH-01-091 | MELK-8a Dihydrochloride | NMS-P715 | MELK-8a hydrochloride | OTSSP167 | MELK-IN-1 | Antitumor agent-116

相关库: Anti-Prostate Cancer Compound Library | Oxidation-Reduction Compound Library | Anti-Cancer Metabolism Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Active Compound Library | Preclinical Compound Library | Covalent Inhibitor Library

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