海南霉素 T21577

Product Introduction
Bioactivity


英文名: Narasin (sodium salt)

描述: Narasin (sodium salt) (HainanMycin) 通过神经胶质瘤细胞中的 ER 应激诱导肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 介导的细胞凋亡，并通过抑制 IκBα 的磷酸化来抑制 NF-κB 信号传导。

体外活性: Narasin caused suicidal erythrocyte death or eryptosis. In human erythrocytes, Narasin increased annexin-V-binding indicating cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface and the decrease of forward scatter reflecting cell shrinkage, which indicated the death of erythrocyte [1].

体内活性: Administration of 4-48 p.p.m of narasin in the pelleted feed of New Zealand White rabbits. After 4 weeks, narasin protected rabbits from severe coccidiosis induced by E. flavescens, E. perforans E. Magna, E. Intestinalis, and E. Stiedai. In addition, narasin reduced oocyst output effectively[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Soluble


关键字: Naracin sodium | Narasin (sodium salt) | Narasin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途