CP 465022 T21584
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 199655-36-2 | ¥3,970.00 | 询底价 |
50 mg | 199655-36-2 | ¥2,930.00 | 询底价 |
25 mg | 199655-36-2 | ¥1,620.00 | 询底价 |
10 mg | 199655-36-2 | ¥768.00 | 询底价 |
1 mL | 199655-36-2 | ¥585.00 | 询底价 |
5 mg | 199655-36-2 | ¥478.00 | 询底价 |
1 mg | 199655-36-2 | ¥196.00 | 询底价 |
500 mg | 199655-36-2 | 面议 | 询底价 |
Product Introduction
Bioactivity
英文名: CP 465022
描述: CP 465022 hydrochloride 是强效的、选择性的AMPA 受体非竞争性拮抗剂,具有抗惊厥活性。CP 465022 hydrochloride 在大鼠皮层神经元中抑制Kainate 诱导的反应 (IC50= 25 nM)。
体外活性: CP 465022 hydrochloride 1 µM for 10 min has little effect on peak NMDA-induced currents but reduces current measured at 8 s during NMDA application by 26%.CP-465,022 at 10 µM inhibits peak NMDA-induced currents in cortical neurons by 36% and currents measured at 8 s by 70% d in primary cultures of cortical and cerebellar granule neurons. CP 465022 hydrochloride (0.0001 μM-10 μM) inhibits kainate-induced response in relatively slow manner and dependents on compound concentration, exhibiting a calculated IC50 of 25 nM and essentially complete inhibition at 3.2 µM. CP 465022 hydrochloride 1 µM for 10 min inhibits peak NMDA currents in cultured rat cerebellar granule neurons with mean inhibition of 19% and NMDA currents measured at 8 s by 45%, similar to what is observed in the cortical neurons. CP 465022 hydrochloride (100 nM -10 µM) has inhibitory effects on Kainate-induced whole-cell currents in voltage-clamped rat hippocampal, 100 nM CP465,022 inhibits kainate currents developed over the course of 200s, 500 nM and 1 µM CP-465,022 nearly complete inhibits this time frame (99.3%)[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.63 mg/mL (10 mM)
关键字: CP 465022 hydrochloride | CP465022 | CP-465022 | CP 465022
相关产品: glycine | Meclofenoxate hydrochloride | Orphenadrine Citrate | Nevadistinel | (RS)-(Tetrazol-5-yl)glycine | Isoxsuprine hydrochloride | PEAQX | LY836 | AMPA receptor modulator-1 | Dasolampanel
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途