化合物FAUC-365 T21667

Product Introduction
Bioactivity


英文名: FAUC-365

描述: FAUC-365 是一种高度选择性的多巴胺D3受体拮抗剂，能够作用于 D3 受体(Ki:0.5 nM)、D4.4 受体(Ki:340 nM)、D2short 受体(Ki:2600 nM)和 D2Long 受体(Ki:3600 nM)。它可用于研究帕金森病、精神分裂症等疾病。

体外活性: As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : insoluble
DMSO : 50 mg/mL (108.12 mM)
EtOH : insoluble


关键字: inhibit | Parkinson's disease | Dopamine Receptor | FAUC365 | D3 receptor | Dopamine | Inhibitor | schizophrenia | SPET | FAUC 365 | Radioligand | FAUC-365

相关产品: SPD-473 citrate | Atomoxetine hydrochloride | Foscarbidopa | PF2562 | FGH31 | Syrosingopine | Trifluoperazine dihydrochloride | Mianserin hydrochloride | Brexpiprazole | Amantadine hydrochloride

相关库: Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | GPCR Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途