藤黄绿菌素 T21771
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 25683-07-2 | ¥2,990.00 | 询底价 |
50 mg | 25683-07-2 | ¥10,600.00 | 询底价 |
1 mg | 25683-07-2 | ¥1,510.00 | 询底价 |
25 mg | 25683-07-2 | ¥7,920.00 | 询底价 |
500 mg | 25683-07-2 | ¥28,800.00 | 询底价 |
100 mg | 25683-07-2 | ¥14,300.00 | 询底价 |
10 mg | 25683-07-2 | ¥4,960.00 | 询底价 |
5 mg | 25683-07-2 | ¥3,490.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Pyoluteorin
描述: Pyoluteorin 是一种抗生素 (antibiotic),可抑制 Oomycete fungi,包括植物病原体 Oomycete fungi,并抑制由该真菌引起的植物病害。 Pyoluteorin 在体外诱导人三阴性乳腺癌 MDA-MB-231 细胞凋亡 (apoptosis)。 Pyoluteorin 可用于人类三阴性乳腺癌的研究。
体外活性: Pyoluteorin is an antifungal compound composed of a bichlorinated pyrrole linked to a resorcinol moiety, were identified within a 24-kb genomic region of Pseudomonas fluorescens Pf-5[1]. Pyoluteorin has significant cytotoxicity towards MCF-7 (IC50=1.84 μM). Pyoluteorin also displays significantly selective cytotoxicity against BT474, HCC1954, MAD-MB-468, MDA-MB-231, and MCF-10A cells with IC50 values of 9.75±0.16, 0.94±0.01, 3.89±0.08, 0.97±0.01, and 57.01±0.76 μM, respectively[2]. Pyoluteorin (0.1-10 μM; for 24 hours) induces change of apoptosis-related protein expressions. Pyoluteorin-induced cell apoptosis in MDA-MB-231 is related to Bcl-2 family proteins and caspase cascade[2]. Pyoluteorin (0.1-10 μM; for 24 h) induces cell cycle arrest and apoptosis in human triple-negative breast cancer cells MDA-MB-231[2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (202.15 mM)
关键字: Pyoluteorin
相关产品: Diiodohydroxyquinoline | Sulfapyridine | Rosoxacin | Pleuromutilin | Erythromycin ethylsuccinate | Darobactin | Cefpodoxime proxetil | Anisomycin | Cephalexin | Phloracetophenone
相关库: Anti-Tumor Natural Product Library | Antibiotics Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Active Compound Library | Natural Product Library for HTS | Microbial Natural Product Library | Anti-infective Natural Product Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途